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目的建立B细胞受体信号途径的动力学模型,通过模型仿真揭示B细胞受体信号途径各分子间的动态调控过程。方法根据数据库KEGG及相关中英文文献,提取B细胞受体信号转导各条通路相关分子作用的方式及数量关系,利用Matlab7.0的Simulink工具箱构建信号途径的动力学模型并仿真。结果模型仿真结果能够从数量上反映B细胞受体信号途径中各分子间复杂的调控关系,并能通过模型仿真发现和验证该信号途径中的关键分子。结论关键分子SYK和BTK活性的动态调节机制控制着B细胞受体信号途径的动力学过程。
OBJECTIVE: To establish a kinetic model of B cell receptor signaling pathway and to reveal the dynamic regulation of B cell receptor signaling pathway through model simulation. Methods Based on the KEGG database and relevant Chinese and English literature, the ways and quantitative relationships of the molecules involved in each pathway of B cell receptor signal transduction were extracted. The kinetic model of the signal pathway was constructed and simulated by Simulink toolbox of Matlab7.0. Results The results of model simulation can quantitatively reflect the complex regulation between molecules in the B cell receptor signaling pathway and can be used to discover and validate the key molecules in this signaling pathway through model simulation. Conclusions The dynamic regulatory mechanism of the key molecule SYK and BTK activity controls the kinetics of the B cell receptor signaling pathway.