论文部分内容阅读
目的探讨ERG蛋白在前列腺癌中的表达及其诊断与鉴别诊断价值。方法采用免疫组化En Vision两步法检测66例前列腺癌和48例良性前列腺增生中ERG蛋白的表达。结果前列腺癌中ERG蛋白(+)6例(9.1%),其中高表达5例(83.3%),低表达者1例(16.7%);ERG在良性前列腺增生中均为(-)。结论 ERG蛋白在我国前列腺癌中的阳性率远低于欧美等国家,具有显著的差异。免疫组化检测ERG蛋白不能用于我国前列腺癌与良性前列腺增生症的诊断与鉴别诊断。
Objective To investigate the expression of ERG protein in prostate cancer and its diagnostic value and differential diagnosis. Methods The expression of ERG protein in 66 cases of prostate cancer and 48 cases of benign prostatic hyperplasia was detected by immunohistochemical En Vision two-step method. Results There were 6 cases (9.1%) of ERG protein (+) in prostate cancer, of which 5 cases (83.3%) had high expression and 1 case (16.7%) had low expression of ERG protein, and (-) ERG in benign prostatic hyperplasia. Conclusion The positive rate of ERG protein in prostate cancer in our country is much lower than that in Europe and the United States, with significant differences. Immunohistochemical detection of ERG protein can not be used for the diagnosis and differential diagnosis of prostate cancer and benign prostatic hyperplasia in our country.