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细小病毒中的某些自主性细小病毒,不但具有干扰肿瘤的“自发”形成特点,而且能有效抑制或杀伤转化细胞和肿瘤细胞.仓鼠溶骨性细小病毒的H-1(Parvovirus H-1,PVH-1)是自主性细小病毒的一种.体内外研究均证实PVH-1对体外培养和体内接种的转化细胞和肿瘤细胞有抑制杀伤作用.用MIT法测定PVH-1对10株细胞包括9株肿瘤细胞和1株人成纤维细胞的作用,并建立荷人肝癌细胞L_C-412裸小鼠模型,分三组,一组为对照组,二组为给药组,其中一组为一次治疗组,一组为二次治疗组,于治疗后不同时间分别测量肝叶上瘤径大小,并做病理检查.同时,应用PVH-l治疗六例人体晚期肝癌,动态观察血清甲胎蛋白和B超变化.
Certain autonomous parvoviruses in parvovirus not only have the characteristic of “spontaneous” formation of interference with tumors, but also can effectively inhibit or kill transforming cells and tumor cells. Hamster osteolytic parvovirus H-1 (Parvovirus H-1, PVH-1) is a kind of autonomous parvovirus. Both in vitro and in vivo studies have confirmed that PVH-1 can inhibit the killing of transformed cells and tumor cells inoculated in vitro and in vivo. PVH-1 was measured by MIT for 10 cells including Nine tumor cell lines and one human fibroblast cell line were used to establish a nude mouse model of human hepatoma cells L_C-412. The mice were divided into three groups. One was the control group, and the other was the drug administration group. In the treatment group, one group was a second treatment group. The diameter of the upper lobe of the liver was measured at different times after treatment, and the pathological examination was performed. At the same time, six cases of advanced human liver cancer were treated with PVH-l, and serum alpha-fetoprotein was dynamically observed. B super changes.