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目的探讨理气散瘀组方穴位敷贴联合米非司酮治疗气滞血瘀型子宫肌瘤的临床疗效。方法选取临西县人民医院2014年6月—2016年3月收治的气滞血瘀型子宫肌瘤患者80例,根据随机数字表法分为对照组和治疗组,各40例。对照组患者入院后给予米非司酮片治疗,治疗组患者在对照组基础上给予理气散瘀组方穴位敷贴治疗,两组患者均持续治疗3个月。比较两组患者的临床疗效,治疗前后子宫体积、子宫肌瘤体积变化情况及孕酮、雌二醇水平。结果治疗期间,对照组患者出现肝功能损伤2例,治疗组患者出现皮肤过敏1例。治疗组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者子宫体积、肌瘤体积比较,差异无统计学意义(P>0.05);治疗后,治疗组患者子宫体积、肌瘤体积小于对照组(P<0.05)。治疗前,两组患者孕酮、雌二醇水平比较,差异无统计学意义(P>0.05);治疗后,治疗组患者孕酮、雌二醇水平低于对照组(P<0.05)。结论采用理气散瘀组方穴位敷贴联合米非司酮治疗气滞血瘀型子宫肌瘤的临床疗效确切,可有效缩小子宫体积和肌瘤体积,降低激素水平,改善临床症状。
Objective To investigate the clinical effects of acupoint application of moxibustion and stasis combined with mifepristone on qi stagnation and blood stasis type uterine fibroids. Methods 80 cases of uterine leiomyoma of qi stagnation and blood stasis type treated in Linxi People’s Hospital from June 2014 to March 2016 were selected and divided into control group and treatment group according to random number table. The patients in the control group were given mifepristone tablets after admission. The patients in the treatment group were treated with acupoints on the basis of the control group, and the patients in both groups were treated continuously for 3 months. The clinical efficacy, the uterine volume before and after treatment, the volume change of uterine fibroids and the progesterone and estradiol levels were compared between the two groups. Results During the treatment period, two cases of liver injury occurred in the control group and one case of skin allergy in the treatment group. The clinical efficacy of the treatment group was better than that of the control group (P <0.05). Before treatment, there was no significant difference in uterine volume and fibroid volume between the two groups (P> 0.05). After treatment, the uterine volume and fibroid volume in the treatment group were smaller than those in the control group (P <0.05). Before treatment, the levels of progesterone and estradiol in the two groups had no significant difference (P> 0.05). After treatment, the levels of progesterone and estradiol in the treatment group were lower than those in the control group (P <0.05). Conclusions The clinical curative effect of qi stagnation and blood stasis group acupoint applying mifepristone in treating qi stagnation and blood stasis uterine fibroids can reduce the uterine volume and myoma volume effectively, reduce the hormone level and improve the clinical symptoms.