将Ｗｉｓｔａｒ大鼠喂养在逐渐降低的常压低氧条件下，用氮气和空气的混合气体调节氧含量。氧浓度由正常含量逐步降低为１５％、１２％、１０％、８％，最后降至７％，实验共进行１１２ｄ。结果显示低氧动物体重下降，肾上腺重量减少，肾上腺皮质球状带萎缩，脂质丢失，球状带细胞线粒体肿胀和空泡变性，溶酶体增多。表明在慢性常压低氧中，当吸入气氧含量降至７％时，可导致肾上腺皮质球状带细胞超微结构改变，从而影响醛固酮的合成与分泌。 Wistar rats were fed under gradually reduced atmospheric hypoxia conditions with a mixture of nitrogen and air to adjust the oxygen content. Oxygen concentration gradually reduced from the normal content of 15%, 12%, 10%, 8%, and finally dropped to 7%, the experiment conducted a total of 112d. The results showed that hypoxia decreased body weight, decreased adrenal weight, cortical atrophy of adrenal cortex, lipid loss, mitochondria swelling and vacuolation of globular zone cells, and increased lysosomes. It shows that in the chronic hypobaric hypoxia, when the inhaled oxygen content is reduced to 7%, the ultrastructure of the cells in the adrenal cortex can be changed, which affects the synthesis and secretion of aldosterone.