神经酰胺(ceramide)是神经鞘脂类的主要成员之一,与细胞的分化、增殖、凋亡及衰老等生命活动息息相关。近来研究发现神经酰胺的合成、代谢及信号转导对肝星状细胞的增殖、凋亡具有重要的调节作用。在肝星状细胞凋亡过程中,神经酰胺可通过激活Bcl-2家族、p53等蛋白介导肝星状细胞的凋亡。本文就近年来神经酰胺对肝星状细胞凋亡机制的研究作一综述。 Ceramide is one of the main members of sphingolipids, and is closely related to the life activities such as cell differentiation, proliferation, apoptosis and aging. Recent studies have found that ceramide synthesis, metabolism and signal transduction of hepatic stellate cell proliferation, apoptosis has an important regulatory role. In the process of hepatic stellate cell apoptosis, ceramide can mediate the apoptosis of hepatic stellate cells by activating the Bcl-2 family, p53 and other proteins. In this paper, in recent years, the mechanism of ceramide on hepatic stellate cell apoptosis is reviewed.