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目的观察安替可胶囊（ａｎｔｉｋｅ）对荷人癌裸鼠的抑瘤作用及其治疗晚期消化道肿瘤的疗效．方法采用ＭＴＴ和人癌细胞克隆形成以及裸鼠荷瘤技术；临床上晚期消化系癌５３２例，其中Ⅱ期１１１例，占２０９％；Ⅲ期２２２例，占４１７％；Ⅳ期１９９例，占３７４％；均经病理证实，全部病例采用数表法随机分组．结果人癌细胞对ａｎｔｉｋｅ的敏感性顺序依次是：Ｍｇｃ８０３≥Ｅｃａ１０９＞ＳＭＭＣ７７２１；Ａｎｔｉｋｅ５００ｍｇ／ｋｇ对Ｍｇｃ８０３，Ｅｃａ１０９和ＳＭＭＣ７７２１人癌细胞裸鼠的瘤重抑制率分别为４７２％，４７２％和４５４％；Ａｎｔｉｋｅ治疗晚期食管癌、肝癌和肠癌２５８例，总缓解率（ＣＲ＋ＰＲ）为７４％，并能显著止痛，改善生存质量和提高免疫功能；放疗＋ａｎｔｉｋｅ治疗晚期食管癌１００例，总缓解率为７２０％，比单纯放疗组（３４４％）提高了３７６％（Ｐ＜００１），同时，能显著改善吞咽困难，明显增加体重，保护血象和降低ＣＥＡ．结论Ｍｇｃ８０３，Ｅｃａ１０９和ＳＭＭＣ７７２１对ａｎｔｉｋｅ较敏感，并且ａｎｔｉｋｅ对其裸鼠移植瘤具有明显抑制作用；Ａｎｔｉｋｅ对食管癌、胃癌、肝癌有较好疗效，同时具有显著放疗增敏作用
Objective To observe the antitumor effect of Antican capsule on nude mice bearing human cancer and its efficacy in the treatment of advanced gastrointestinal cancer. Methods MTT and human cancer cells were used for cloning and nude mice bearing tumors. There were 532 cases of advanced gastrointestinal cancer in the clinic, including 111 cases of stage II (20.9%) and 222 cases of stage III (41.7%). 199 cases, accounting for 37.4%; all confirmed by pathology, all cases were randomly divided into groups using the table method. Results The sensitivity sequence of human cancer cells to antik was: Mgc803 ≥ Eca109> SMMC7721; Antike 500 mg/kg inhibited the tumor weight of Mgc803, Eca109 and SMMC7721 human cancer cells in nude mice by 47. 2% and 47. 2%, respectively. 45.4%; Antike treatment of advanced esophageal cancer, liver cancer and colorectal cancer in 258 cases, the total remission rate (CR + PR) of 7.4%, and can significantly relieve pain, improve the quality of life and improve immune function; radiotherapy +antike treatment of advanced esophageal cancer 100 The total remission rate was 72.0%, which was an increase of 37.6% compared with the radiotherapy group (34.4%) (P<0. 01). At the same time, it significantly improved dysphagia, increased body weight significantly, and protected blood and Lower CEA. Conclusion Mgc803, Eca109 and SMMC7721 are more sensitive to antikine, and antike has a significant inhibitory effect on transplanted tumor in nude mice; Antike has good curative effect on esophageal cancer, gastric cancer and liver cancer, and has significant radiosensitization effect at the same time.