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目的:探讨住院2型糖尿病（T2DM）患者肾小管损伤指标尿视黄醇结合蛋白（RBP）和βn 2-微球蛋白（βn 2-MG）与尿白蛋白/肌酐比值（UACR）和肾功能的相关性。n 方法:收集北京大学人民医院住院T2DM患者1 030例，比较UACR正常组（300 mg/g）的尿RBP和βn 2-MG水平；UACR正常患者根据估算的肾小球滤过率（eGFR）分为eGFR下降组（370 μg/L) in these groups were 3.8%, 8.5%, 39.0% (n P<0.001), and 12.9%, 26.7%, 46.8% (n P<0.001), respectively. In the UACR normal group (n n=788), 12.2% of the patients were with eGFR370 μg/L) was higher in the eGFR low group than that in the eGFR normal group (29.2% vs. 10.7%,n P<0.001). Multivariate linear stepwise regression analyses were performed using natural logarithm of urine RBP or βn 2-MG as dependent variable, and showed that urine RBP was independently associated with UACR (n β=0.0005, n P<0.001), serum creatinine (n β=0.006, n P<0.001) and glycosylated hemoglobin A1c (n β=0.050, n P=0.001), and βn 2-MG was independently correlated with UACR (n β=0.000 4, n P<0.001), serum creatinine (n β=0.011, n P<0.001), systolic blood pressure (n β=0.005, n P=0.031) and fasting blood-glucose (n β=0.027, n P=0.046).n Conclusions:Urine RBP and βn 2-MG are positively associated with high UACR and impaired renal function in T2DM patients, and these changes could occur before UACR and eGFR turned out to be abnormal. It is recommended that urine RBP and βn 2-MG be detected as early as possible to identify diabetic kidney disease in patients with normal UACR and eGFR.n