论文部分内容阅读
目的观察前列环素 Ⅰ_２（ＰＧＩ_２）雾化吸入治疗犬油酸型急性呼吸窘迫综合征（ＡＲＤＳ）对血液动力学、血气、呼吸功能及肺组织病理等影响。方法以０．１１ｍｌ／ｋｇ油酸致犬急性肺损伤后，随机分为２组， Ⅰ组为对照组（ｎ＝５），单纯行机械通气治疗； Ⅱ组为ＰＧＩ_２雾化吸入治疗组（ｎ＝６），分别以５、１０、２０、３０ｎｇ·ｋｇ~－１·ｍｉｎ~－１的ＰＧＩ_２雾化吸入治疗１５分钟，间隔１５分钟；然后以２０ｎｇ·ｋｇ~－１·ｍｉｎ~－１持续雾化吸入 １小时。观察血液动力学指标、动脉血气、肺动态顺应性（Ｃｄｙｎ）等变化，同时进行肺组织病理学检查和肺组织湿／干（Ｗ／Ｄ）比值测定，综合评价治疗效果。结果 ＰＧＩ_２ ２５ｎｇ· ｋｇ－１·ｍｉｎ~－１即能显著增加 Ｃｄｙｎ，１０～３０ｎｇ· ｋｇ~－１· ｍｉｎ~－１时，ＰＡＰ显著降低（Ｐ＜０． ０５），ＭＡＰ基本保持正常；２０～３０ｎｇ· ｋｇ~－１· ｍｉｎ－１时，ＰａＯ_２显著升高，Ｑｓ／Ｑｔ则显著下降（Ｐ＜０． ０５）；治疗后２小时，对照组ＰＣＷＰ升高，ＭＡＰ降低（Ｐ＜０．０５），而实验组无显著变化。此外，实验组Ｗ／Ｄ显著下降（Ｐ＜０．０５）；病理学检查肺组织损害明显减轻。结论ＰＧＩ_２能选择?
Objective To observe the effects of inhalation of prostacyclin Ⅰ_2 (PGI_2) on hemodynamics, blood gas, respiratory function and lung histopathology in dogs with oleic acid acute respiratory distress syndrome (ARDS). Methods Acute lung injury induced by 0.11ml / kg oleic acid was divided into two groups at random: group Ⅰ (n = 5) and mechanical ventilation alone; group Ⅱ (n = 5) = 6), inhaled for 15 minutes with PGI_2 of 5, 10, 20, 30 ng · kg -1 · min -1, respectively, for 15 minutes and then continued for 20 ng · kg -1 · min -1 Inhalation for 1 hour. The changes of hemodynamics, arterial blood gas and dynamic compliance of lung (Cdyn) were observed. The lung histopathology and W / D ratio of lung tissue were also measured to evaluate the therapeutic effect. Results PGI 2 at 25 ng · kg -1 · min -1 could significantly increase Cdyn, MAP decreased at 10 ~ 30 ng · kg -1 -1 min -1 (P <0.05) PaO2 was significantly increased and Qs / Qt was significantly decreased (P <0.05) at 30ng kg-1min-1. PCWP was increased and MAP was decreased at 2h after treatment in control group (P <0. 05), while no significant changes in the experimental group. In addition, the experimental group W / D decreased significantly (P <0.05); pathological examination significantly reduced lung tissue damage. Conclusion PGI_2 can choose?