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自1977年Takatsuki 等报告了HTLV—Ⅰ病毒抗体以后,日本发现在成人T 细胞白血病(ATL)患者血清中几乎都存在这种抗体。被确诊为ATL 的患者也有所增加。估计日本有200人以上死于此病。目前认为ATL 的病因是HTLV—Ⅰ病毒感染。在日本此病毒的携带者超过50万人。1.ATL 的临床特点:①成人发病,②患者的末梢血液中T 细胞往往有核转移和核分叶倾向,③皮肤病变,肝脾及淋巴结肿大率高,④多数患者有轻度贫血及轻度骨髓浸润,⑤患者常有高血Ca~(++)症,⑥日本患者主要集中在九州、冲绳、四国等地,⑦治疗效果很差,急性型患者平均4个月死亡。呼吸道感染、真菌
Since Takatsuki et al reported antibody to HTLV-I in 1977, it was found in Japan that almost all the antibodies were present in the sera of patients with adult T-cell leukemia (ATL). Patients diagnosed with ATL also increased. More than 200 people in Japan are estimated to have died of the disease. At present, the cause of ATL is HTLV-I virus infection. More than 500,000 people are carriers of this virus in Japan. 1.ATL clinical features: ① adult onset, ② patients with peripheral T cells tend to have nuclear metastasis and nuclear lobular tendencies, ③ skin lesions, liver and spleen and lymph node enlargement rate, ④ most patients with mild anemia and Mild bone marrow infiltration, ⑤ patients often have high blood Ca ~ (++) disease, ⑥ Japanese patients are mainly concentrated in Kyushu, Okinawa, Shikoku and other places, ⑦ poor treatment, acute type patients died an average of 4 months. Respiratory tract infections, fungi