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目的探讨2型糖尿病患者并发动脉粥样硬化(AS)的影响因素。方法选取2013年4月—2015年4月海南省人民医院内分泌科收治的2型糖尿病患者142例,根据颈动脉内-中膜厚度(IMT)分为AS组(IMT>1.3mm,n=75)和非AS组(IMT≤1.3 mm,n=67)。比较两组患者一般资料及实验室指标,给予两组患者降糖、降压、降血脂、控烟等对症处理,观察两组患者半年后AS情况。结果两组患者性别、病程比较,差异无统计学意义(P>0.05);AS组≥45岁患者所占比例、>24 kg/m~2患者所占比例、高血压发生率、糖尿病家族史阳性率、吸烟史阳性率均高于非AS组(P<0.05)。两组患者空腹血糖(FBG)、糖化血红蛋白(HbA_(1c))、尿酸(UA)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)比较,差异无统计学意义(P>0.05);AS组患者餐后2 h血糖(2 h PG)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均高于非AS组(P<0.05)。随访半年后,AS组67例(89.3%)患者动脉硬化程度有所缓解,非AS组仅8例(11.9%)患者出现AS。结论年龄、BMI、高血压、糖尿病家族史、吸烟史、2 h PG、TG、LDL-C是2型糖尿病患者并发AS的影响因素,降糖、降压、降血脂、控烟等是降低2型糖尿病患者并发AS的有效措施。
Objective To investigate the influencing factors of atherosclerosis (AS) in type 2 diabetic patients. Methods A total of 142 type 2 diabetic patients admitted to Department of Endocrinology of Hainan Provincial People ’s Hospital from April 2013 to April 2015 were divided into two groups according to carotid intima - media thickness (IMT): AS group (IMT> 1.3mm, n = 75) ) And non-AS group (IMT≤1.3 mm, n = 67). The general data and laboratory indexes of two groups of patients were compared. The patients in both groups were given hypoglycemic, antihypertensive, hypolipidemic and tobacco control symptomatic treatment. The AS of the two groups were observed after six months. Results There was no significant difference in gender and duration between the two groups (P> 0.05). The proportion of patients with AS in 45 years or more, the proportion of patients with> 24 kg / m ~ 2, the incidence of hypertension, family history of diabetes Positive rate and smoking history were higher than non-AS group (P <0.05). There was no significant difference in fasting blood glucose (FBG), HbA 1c, UA, TC and HDL-C between the two groups (P> 0.05 ). The 2 h PG, triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) levels of patients in AS group were significantly higher than those in non-AS group (P <0.05). Six months after follow-up, 67 patients (89.3%) in AS group were relieved of atherosclerosis and only 8 patients (11.9%) in non-AS group showed AS. Conclusions Age, BMI, hypertension, family history of diabetes, smoking history, 2 h PG, TG and LDL-C are the influencing factors of AS in type 2 diabetic patients. Hypoglycemic, antihypertensive, Diabetic patients complicated by AS effective measures.