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目的 :探讨 P2 7、P5 3和增殖细胞核抗原 (PCNA)在胃癌组织中的表达及其与临床病理指标及预后的相关性。方法 :应用免疫组织化学 SP法 ,检测 6 2例人胃癌组织中 P2 7、P5 3、PCNA的表达。结果 :胃癌组织中 ,P2 7、P5 3、PCNA表达的阳性率分别为 37.1%、40 .4%、83.9%。 P2 7的表达与 Bormann分型、肿瘤浸润深度、淋巴结及远处转移、临床分期有关 ;P5 3表达与患者性别、远处转移、临床分期有关 ;而 PCNA仅与患者年龄、肿瘤分化程度有关。P2 7阳性组 5年生存率高于阴性组 ,P2 7与 PCNA表达呈显著负相关。 结论 :胃癌组织中 P2 7、P5 3、PCNA的表达可作为判断肿瘤恶性程度、有无转移及预后的重要参考指标。
Objective: To investigate the expression of P2 7, P5 3 and PCNA in gastric carcinoma and its relationship with clinicopathological parameters and prognosis. Methods: The expressions of P2 7, P5 3 and PCNA in 62 cases of human gastric carcinoma were detected by immunohistochemical SP method. Results: The positive rates of P2 7, P5 3 and PCNA in gastric cancer tissues were 37.1%, 40.4% and 83.9%, respectively. The expression of P2 7 was related to Bormann classification, tumor invasion depth, lymph node and distant metastasis, and clinical stage. The expression of P53 was related to the gender, distant metastasis and clinical stage. PCNA was only related to patient’s age and tumor differentiation. The 5-year survival rate of P2 7 positive group was higher than that of negative group, while P2 7 was negatively correlated with PCNA expression. Conclusion: The expression of P2 7, P5 3 and PCNA in gastric cancer can be used as an important reference index to determine the degree of malignancy, metastasis and prognosis.