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目的评价MRI扩散张量成像(DTI)技术在早期帕金森病(PD)中的诊断价值。资料与方法对30名早期PD患者和30例匹配的健康老年对照组的黑质-纹状体区进行了常规MR平扫和DTI扫描,对双侧黑质-纹状体纤维环路穿越的部位:黑质致密部、底丘脑核、苍白球、壳核、尾状核连续层面的FA值和DCavg值进行测量和统计分析。结果PD组黑质致密部、黑质致密部与底丘脑核之间部位的FA值显著低于对照组(P值<0.05)。苍白球、壳核、尾状核等部位的FA值和DCavg值与对照组相比无显著差异。结论DTI能无创性定量测量早期PD黑质-纹状体区病变的FA值和DCavg值,是对早期PD黑质-纹状体区进行定量评估的一种敏感的研究手段。
Objective To evaluate the diagnostic value of MRI diffusion tensor imaging (DTI) in early stage Parkinson’s disease (PD). Materials and Methods Routine MR plain scan and DTI scan of substantia nigra and striatum in 30 early PD patients and 30 matched healthy controls were performed. The bilateral nigrostriatal Location: The substantia nigra pars compacta, the subthalamic nucleus, the globus pallidus, the putamen, the caudate nucleus of the continuous layer of FA values and DCavg values were measured and statistical analysis. Results The FA value in substantia nigra pars compacta, substantia nigra pars compacta and subthalamic nucleus in PD group was significantly lower than that in control group (P <0.05). Pallidum, putamen, caudate nucleus and other parts of the FA value and DCavg values compared with the control group no significant difference. Conclusion DTI can be a noninvasive and quantitative method to measure the FA and DCavg values of early PD nigrostriatum lesions. It is a sensitive method for quantitative evaluation of early substantia nigra and striatum in PD.