建议了一个新的HMQC实验的脉冲序列 ,其准备期和混合期分别为 90°x(1H) -τ/ 2-1 80°x(1H ,13C) -τ/ 2 -90°x(1H ,13C)和 90°x(13C) -τ/ 2 -1 80°x(1H ,13C) -τ/ 2 -,以及τ=(2JCH) - 1(JCH为C H偶合常数 ) .在这个新的HMQC实验中 ,与碳 1 2相连质子的信号被有效地抑制 ,其抑制的机理与脉冲的相位循环无关 .从而 ,它可以用于有效地抑制HMQC谱的噪音 .特别是 ,在没有脉冲梯度场装置时 ,该方法显得非常实用 A new pulse sequence of HMQC experiment is proposed with a preparation period and mixing period of 90 ° x (1H) -τ / 2-1 80 ° x (1H, 13C) -τ / 2 -90 ° x 13C) and 90 ° x (13C) -τ / 2 -180 ° x (1H, 13C) -τ / 2 - and τ = (2JCH) -1 (JCH is the CH coupling constant.) In this new HMQC In the experiment, the signal of proton attached to carbon 12 is effectively suppressed, and the mechanism of its inhibition is independent of the phase of the pulse, so that it can be used to effectively suppress the noise of the HMQC spectrum.In particular, in the absence of a pulse gradient field device This method is very practical