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目的了解不同剂量的阿托伐他汀治疗脑梗死的临床效果。方法 100例脑梗死患者,随机分为甲组和乙组,各50例。在常规治疗基础上,甲组患者采用40 mg的阿托伐他汀治疗,乙组患者采用20 mg的阿托伐他汀治疗,对比两组患者的治疗效果。结果甲组患者的治疗总有效率为96%,乙组患者的治疗总有效率为82%,甲组的治疗效果优于乙组,差异有统计学意义(P<0.05);经过治疗后,甲组患者的美国国立卫生院神经功能缺损评分(NIHSS)为(3.5±0.6)分,乙组NIHSS评分为(6.7±1.4)分,甲组NIHSS评分明显低于乙组,差异有统计学意义(P<0.05);甲组患者的血脂水平及血清超敏C-反应蛋白水平的下降程度高于乙组,差异有统计学意义(P<0.05);两组患者未在治疗过程中出现明显不良反应。结论使用大剂量的阿托伐他汀治疗脑梗死,能够降低血脂水平,显著改善患者的神经功能缺损,取得更好的治疗效果,减低脑血管疾病的风险。
Objective To understand the clinical effects of different doses of atorvastatin on cerebral infarction. Methods 100 patients with cerebral infarction were randomly divided into group A and group B, 50 cases each. On the basis of routine treatment, 40 mg of atorvastatin in group A and 20 mg of atorvastatin in group B were compared with those of the two groups. Results The total effective rate of treatment in group A was 96%, that in group B was 82%, and that in group A was better than that in group B (P <0.05). After treatment, The NIH score of NIH was 3.5 ± 0.6 in group A, NIHSS in group B was 6.7 ± 1.4, NIHSS in group A was significantly lower than that in group B, the difference was statistically significant (P <0.05). The level of serum lipids and the level of serum high-sensitivity C-reactive protein in group A were significantly lower than that in group B (P <0.05). There was no significant difference between the two groups in the course of treatment Adverse reactions. Conclusions The use of large doses of atorvastatin in the treatment of cerebral infarction can reduce the level of blood lipids, significantly improve the patients’ neurological deficits, achieve better therapeutic effects and reduce the risk of cerebrovascular diseases.