论文部分内容阅读
目的:探讨SD大鼠经口灌胃纳米二氧化钛的亚慢性毒性,观察其引起的毒性反应,提供毒性反应的靶器官。方法:以1g/kg剂量反复经口灌胃纳米和微米二氧化钛,连续给予13周,每天1次,染毒末测定纳米和微米二氧化钛对大鼠体重、摄食量、生化、血液学指标和组织病理学等方面的变化。结果:灌胃纳米二氧化钛后均无异常征状可见,观察期间也未见动物出现明显毒性反应和死亡。动物的摄食量、体重变化、血液学指标与对照组或微米二氧化钛组相比,没有显著性改变。生化检查结果显示,与对照组或微米二氧化钛组相比,部分参数差异显著,所有动物的组织学病理观察未见明显的病理学改变。结论:在本试验条件下,纳米二氧化钛与微米二氧化钛相似,未见明显的毒性反应,但对血液生化指标可能有一定的影响。
OBJECTIVE: To investigate the sub-chronic toxicity of nano-titania by oral gavage in SD rats and to observe its toxicity and to provide a target organ for toxic reactions. Methods: The nanometer and micronized titanium dioxide were orally administered orally at a dose of 1g / kg for 13 consecutive days once a day. The body weight, food intake, biochemical, hematological parameters and histopathology Neo-Confucianism and other changes. Results: No abnormal symptoms were observed after gavage of nano-titanium dioxide. No obvious toxic reaction and death occurred in animals during the observation period. There was no significant change in food intake, body weight changes and hematological indexes of animals compared with control group or micronized titanium dioxide group. Biochemical tests showed that compared with the control group or the micronized titanium dioxide group, some parameters were significantly different, and no significant pathological changes were observed in all animal histological and histological examination. Conclusion: Under the experimental conditions, the nano-titanium dioxide and titanium dioxide similar to titanium dioxide, no obvious toxicity, but the blood biochemical indicators may have a certain impact.