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目的以CT作为参照,对频率选择饱和法成像及梯度双回波化学位移法成像量化评估脂肪肝进行对比研究。方法 20例弥漫性脂肪肝病例同期行CT及MRI检查,分别对肝Ⅵ段及Ⅳ段(Couinaud法)选取同一位置感兴趣区(ROI)进行测量。对经两种脂肪抑制方法所计算出的脂肪信号比例(FSF)FSF1、FSF2进行配对t检验,对FSF1、FSF2、肝/脾CT值比值(L/S)两两进行Spearman相关性分析。结果 FSF1与FSF2差异有高度统计学意义(P<0.01);FSF1与L/S的相关系数为-0.696(P<0.01),FSF2与L/S的相关系数为-0.904(P<0.01),FSF1与FSF2的相关系数为0.719(P<0.01)。结论与频率选择饱和法成像相比,梯度双回波化学位移法成像与CT量化评估脂肪肝具有较好的相关性,可成为临床量化评估脂肪肝的一种简单、有效的方法。
Objective To compare and evaluate the quantitative evaluation of fatty liver by frequency selective saturation imaging and gradient double-echo chemical shift imaging with CT as a reference. Methods Twenty cases of diffuse fatty liver disease underwent CT and MRI examinations in the same period. The ROIs of the same location in the Ⅵ and Ⅳ of the liver were measured respectively. Spearman correlation analysis of FSF1, FSF2, and liver / spleen CT value ratio (L / S) was performed by paired t-test with fat signal ratio (FSF) FSF1 and FSF2 calculated by two fat suppression methods. Results The correlation between FSF1 and L / S was -0.696 (P <0.01), and the correlation coefficient between FSF2 and L / S was -0.904 (P <0.01). There was a significant difference between FSF1 and FSF2 (P <0.01) The correlation coefficient between FSF1 and FSF2 was 0.719 (P <0.01). Conclusion Gradient double-echo chemical shift imaging and CT quantitative assessment of fatty liver have good correlation with frequency selective saturation imaging, which can be used as a simple and effective method for clinical quantification of fatty liver.