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目的:观察慢性鼻-鼻窦炎筛窦黏膜中基底膜的厚度变化。方法:采用HE染色观察并测量10例对照组、35例慢性鼻-鼻窦炎不伴息肉(CRSsNP)及40例慢性鼻-鼻窦炎伴息肉(CRSwNP)和12例复发性CRS基底膜的厚度。结果:基底膜的厚度在对照组为(7.8±1.3)μm,CRSsNP组为(25.4±4.3)μm,CRSwNP组为(34.7±5.1)μm,复发组为(36.2±6.3)μm,与对照组比较,慢性鼻-鼻窦炎组及复发性CRS组的基底膜厚度有显著性差异(P<0.05)。结论:在慢性鼻-鼻窦炎中,基底膜增厚,尤其是在CRSwNP和复发性慢性鼻-鼻窦炎中,基底膜增厚更为明显。基底膜增厚在慢性鼻-鼻窦炎的发病机制中起重要作用,其意义有待进一步探讨。
Objective: To observe the changes of basement membrane thickness in the ethmoid sinus of chronic rhinosinusitis. Methods: The thickness of CRSsNP and CRSwNP in 40 patients with CRSwNP and 12 patients with recurrent CRS were observed and measured by HE staining. Results: The thickness of the basement membrane was (7.8 ± 1.3) μm in the control group, (25.4 ± 4.3) μm in the CRSsNP group, (34.7 ± 5.1) μm in the CRSwNP group and (36.2 ± 6.3) μm in the CRSwNP group, Compared with chronic rhinosinusitis group and recurrent CRS group, the basement membrane thickness was significantly different (P <0.05). CONCLUSIONS: In chronic rhinosinusitis, thickening of the basement membrane, especially in CRSwNP and recurrent chronic rhinosinusitis, is more pronounced with basement membrane thickening. Basement membrane thickening plays an important role in the pathogenesis of chronic rhinosinusitis, its significance needs to be further explored.