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目的探讨慢性乙型肝炎患者不同血脂指标的表达水平及其与病情轻重和HBV DNA的关系。方法 收集2011年1月至2012年10月宁波市第二医院142例慢性乙型病毒性肝炎患者以及44名健康献血员血清,检测总胆固醇(TCHO)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、载脂蛋白E(ApoE)、脂蛋白a及HBV DNA,对检测结果进行统计学分析。结果 不同病情及不同HBV DNA载量慢性乙型肝炎患者ApoE水平均显著高于正常对照组(P均<0.05);而其他各血脂指标均低于正常对照组(P均<0.05)。ApoE含量与病情轻重呈正相关,而T-CHO、HDL-C、ApoA1则呈负相关。HDL-C、ApoA1含量与HBV DNA载量呈正相关,而T-CHO、LDL-C、ApoB、ApoE则呈负相关。结论 慢性乙型肝炎患者血脂水平受肝脏合成功能以及HBV本身等多种因素的影响。
Objective To investigate the expression of different blood lipid markers in patients with chronic hepatitis B and its relationship with severity of disease and HBV DNA. Methods Totally 142 patients with chronic hepatitis B and 44 healthy blood donors were collected from the Second Hospital of Ningbo City from January 2011 to October 2012. The levels of total cholesterol (TCHO), high density lipoprotein cholesterol (HDL-C) , Low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), apolipoprotein E (apoE), lipoprotein a and HBV DNA were measured. . Results The levels of ApoE in patients with chronic hepatitis B were significantly higher than those in normal controls (P <0.05). However, the levels of other lipids were lower than those in normal controls (all P <0.05). The content of ApoE was positively correlated with the severity of the disease, but negatively correlated with T-CHO, HDL-C and ApoA1. HDL-C, ApoA1 content and HBV DNA load was positively correlated, but T-CHO, LDL-C, ApoB, ApoE was negatively correlated. Conclusion The level of serum lipids in patients with chronic hepatitis B is influenced by many factors, such as liver synthesis and HBV itself.