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目的探讨幽门螺杆菌(Helicobacter pylori,Hp)感染与胃癌发生及预后的关系。方法选取胃癌组织标本78例及其癌旁组织标本26例,采用实时荧光定量聚合酶链反应(PCR)检测胃癌组织和癌旁组织中Hp相对感染量,分析Hp相对感染量与胃癌患者临床病理特征及预后的相关性。结果胃癌组织Hp相对感染量明显高于癌旁组织,且同一患者胃癌组织中Hp相对感染量亦高于其癌旁组织,差异有统计学意义(P<0.01)。胃癌组织中Hp相对感染量与患者临床分期、浸润深度及有无淋巴结转移密切相关,差异有统计学意义(P<0.01),而与性别、年龄、组织学分型及有无远处转移无关,差异无统计学意义(P>0.05)。生存分析结果显示,患者生存率与胃癌组织中Hp相对感染量呈负相关,且差异有统计学意义(P<0.05)。结论 Hp感染可能参与胃癌的发生、发展及转移,可作为临床上评估胃癌进展和预后的潜在指标。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and the occurrence and prognosis of gastric cancer. Methods Seventy-eight gastric cancer specimens and 26 specimens of paracancerous tissues were collected. Real-time fluorescence quantitative polymerase chain reaction (PCR) was used to detect the relative Hp infection in gastric cancer tissues and paracancerous tissues. The correlation between Hp infection and clinical pathological changes Correlation of features and prognosis. Results The relative infection of Hp in gastric cancer tissues was significantly higher than that in adjacent tissues, and the relative infection of Hp in gastric cancer was also higher than that in adjacent tissues (P <0.01). The relative infection of Hp in gastric cancer tissues was closely related to clinical stage, depth of invasion and lymph node metastasis, with significant difference (P <0.01), but not with gender, age, histological type and distant metastasis, The difference was not statistically significant (P> 0.05). Survival analysis showed that the survival rate was negatively correlated with the relative Hp infection in gastric cancer tissues, and the difference was statistically significant (P <0.05). Conclusions Hp infection may be involved in the occurrence, development and metastasis of gastric cancer, which may be used as a potential clinical indicator to evaluate the progress and prognosis of gastric cancer.