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目的：研究乙醇溶液中维生素 Ｄ 原体浓度对它的光异构反应产物产率的影响。方法：用两种紫外光激发光源光照不同浓度的维生素 Ｄ 原体乙醇溶液，使用正相 Ｈ Ｐ Ｌ Ｃ 系统定量测定主要光异构物在溶液中的浓度。结果：数据表明，随维生素 Ｄ 原体浓度的增加，速甾醇产率减少，而光甾醇产率明显增加。维生素 Ｄ 前体产率变化，与所用的激发光源有关。结论：维生素 Ｄ 原体浓度对其光异构反应产物产率的影响较大，特别对速甾醇和光甾醇，利用光自吸收效应有助于设计光化学法合成药物及制备高产率的光异构产物。
Objective: To study the effect of vitamin D in ethanol solution on the yield of its photoisomerization product. Methods: Two kinds of UV light sources were used to illuminate different concentrations of vitamin D precursor ethanol solution. Quantitative determination of the main optical isomers in the solution was carried out using a normal phase HPLC system. Results: The data show that as the concentration of vitamin D is increased, the rate of strontium decreases and the rate of production of sterol increases significantly. Vitamin D precursor yield changes, and the use of the excitation light source. CONCLUSION: The concentration of vitamin D has a great influence on the yield of photoisomerization products. Especially for the photostabolites and photostabolites, the self-absorption of light is helpful to the design of photochemical synthesis of drugs and the preparation of high yield of photoisomerization products .