目的：研究抗人ＩｇＭ（ａｎｔｉμ）在体外对表面ＩｇＭ阳性的人类Ｂ淋巴瘤细胞株ＭＢＣ１细胞及Ｍｏｒａ细胞增殖活性的影响，并探讨其可能的作用机制。方法：应用细胞形态学、流式细胞仪分析及ＤＮＡ凝胶电泳等。结果：测得ａｎｔｉμ对ＭＢＣ１细胞增殖有抑制作用，并存在剂量和时间相关性，而对Ｍｏｒａ细胞则无此作用；并证实ＭＢＣ１细胞的死亡是通过细胞凋亡引起的，具有凋亡的分子水平和形态学特征。结论：ＭＢＣ１细胞可作为研究人类Ｂ细胞表面抗原受体交联所致凋亡的一个实验模式，并为探讨凋亡在个体发育时免疫耐受形成过程中所起的作用提供了良好的实验依据。 Objective: To investigate the effect of anti-human IgM (antiμ) on the proliferation activity of surface IgM positive human B-lymphoma cell line MBC1 and Mora cells in vitro, and to explore its possible mechanism. Methods: The application of cell morphology, flow cytometry analysis and DNA gel electrophoresis. RESULTS: Antiμ was determined to have an inhibitory effect on the proliferation of MBC1 cells and was dose- and time-dependent, but not on Mora cells, and it was confirmed that MBC1 cell death was caused by apoptosis. Molecular level and morphological features with apoptosis. Conclusion: MBC1 cells can be used as an experimental model to study the apoptosis induced by cross-linking of human B-cell surface antigen receptors, and provide a good understanding of the role of apoptosis in the development of immune tolerance in the ontogeny. Experimental basis.