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目的:探讨地黄管食通口服液对食管癌放疗后大鼠的作用机制。方法:采用甲基戊基亚硝胺(MANA)皮下注射(5mg/kg)诱发大鼠食管癌,大鼠食管局部60Co照射后,分别给予相应的受试药物5周,实验结束后采血清并应用酶联免疫吸附法(ELISA)检测血清中细胞因子TGF-β1的含量。结果:地黄管食通口服液可以调节TGF-β1的分泌,抑制其过度表达。结论:地黄管食通口服液可能通过调节机体免疫,并增强机体对TGF-β1反应性,使其逐渐恢复正常的生理作用,同时该药还可能通过直接调节细胞因子的分泌及功能而起到抑制肿瘤细胞再生的作用。
Objective: To investigate the mechanism of dihuangguanshetong oral liquid on rats after esophageal cancer radiotherapy. METHODS: Rats with esophageal cancer were induced by subcutaneous injection of methyl amylnitrosamine (MANA) (5 mg/kg). After 60Co irradiation in the esophagus of rats, the corresponding test drug was given for 5 weeks. Serum was collected after the end of the experiment. The serum cytokine TGF-β1 was detected by enzyme-linked immunosorbent assay (ELISA). Results: Dihuangguanshaotong oral liquid can regulate the secretion of TGF-β1 and inhibit its overexpression. Conclusion: Dihuangguanshaotong Oral Liquid may regulate immune response and enhance the body’s responsiveness to TGF-β1, gradually returning to its normal physiological effects. The drug may also be inhibited by directly regulating the secretion and function of cytokines. The role of tumor cell regeneration.