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已知许多药物,特别是肼苯哒嗪,普鲁卡因酰胺都可诱发原发性系统性红斑狼疮。自从Raftery等首次报道关于心得宁及Harrison等关于可能由心得安引起红斑狼疮的报告以来,认为β-肾上腺素能阻滞剂同样可诱发系统性红斑狼疮。本文报道1例在心得静治疗过程中发生红斑狼疮的患者。病者63岁男性,于1973年2月因尘肺影响而发生下侧壁心肌梗死,患者接受了肝素和氟苯茚满二酮(Fluorophenylindanedione)治疗。1973年4月因严重心绞痛入院,加用心得静5 mg每日3次口服。1975年6月末患者又因发热(38.5℃)、严重胸痛及多发性关节痛而再次入院。血清酶正常,红细胞计数390万/mm~3,白细胞计数3200/mm~3,血沉112mm/h,
It is known that many drugs, especially hydralazine and procainamide, can induce primary systemic lupus erythematosus. Beta-adrenergic blockers have also been suggested to induce systemic lupus erythematosus since Raftery et al. First reported the report of nadine and Harrison et al. On possible lupus erythematosus. This article reports a case of lupus erythematosus in the process of static treatment of patients. The patient, 63 years old, had a transmural myocardial infarction in February 1973 due to pneumoconiosis. He was treated with heparin and Fluorophenylindanedione. April 1973 due to severe angina hospitalization, plus experience calm 5mg 3 times a day orally. At the end of June 1975, the patient was re-admitted due to fever (38.5 ° C), severe chest pain and multiple joint pains. Serum enzyme normal, erythrocyte count 3.9 million / mm ~ 3, white blood cell count 3200 / mm ~ 3, erythrocyte sedimentation rate 112mm / h,