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目的观察自体骨髓干细胞治疗糖尿病足的临床疗效。方法6例糖尿病足患者,体外分离出单个核细胞制成细胞悬液进行肌肉内局部注射。术前、术后进行肢体疼痛、冷感,皮肤温度,踝肱指数评分。结果移植后3月,6例患者疼痛明显缓解,患肢冷感有不同程度改善,各项观察指标差别有显著性。无明显不良反应。结论自体骨髓干细胞移植治疗糖尿病足可有效改善症状。
Objective To observe the clinical efficacy of autologous bone marrow stem cells in the treatment of diabetic foot. Methods Six patients with diabetic foot were isolated from mononuclear cells in vitro to prepare cell suspension for intramuscular injection. Preoperative and postoperative limb pain, cold sensation, skin temperature, ankle brachial index score. Results Three months after transplantation, the pain relief was significantly relieved in 6 patients and the cold sensation in the affected limbs improved to some extent. There was a significant difference between the observation indexes. No obvious adverse reactions. Conclusion Autologous bone marrow stem cell transplantation for the treatment of diabetic foot can effectively improve the symptoms.