安妥明对胰岛素依赖型糖尿病患者不仅有降血脂作用,且尚有降低血浆游离脂肪酸和酮体的效应。作者用双盲交叉法估计安妥明对胰岛素依赖型糖尿病患者的代谢效应。11名患者均已对胰岛素依赖3年以上,无内源性胰岛素分泌;全部患者采用美国糖尿病协会制定的饮食标准;年龄为22～69岁;体重在标准体重10%范围内。在为期3个月的研究期间,病人饮食和每日胰岛素剂量不变并保持院外日常的活动量. Clofibrate does not only have a hypolipidemic effect on insulin-dependent diabetes mellitus, but also has the effect of lowering plasma free fatty acids and ketone bodies. The authors used double-blind crossover to estimate the effect of clopidogrel on insulin-dependent diabetes mellitus. All 11 patients had already been dependent on insulin for more than 3 years and had no endogenous insulin secretion. All patients adopted the dietary standards developed by the American Diabetes Association; their ages ranged from 22 to 69 years; their body weights were within 10% of the standard body weight. During the three-month study period, patient diet and daily insulin dosage remained unchanged and routine daily activity outside the hospital was maintained.