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应用逆转录聚合酶链反应方法定量检测了10例正常人前列腺、20例前列腺增生（BPH）组织及前列腺癌细胞系PC－3m中80ku白细胞介素－6受体（IL－6R）基因表达水平。结果发现正常前列腺组织中IL－6RmRNA呈低水平表达，而43PH组织中表达增强，明显高于正常组（P＜0．01），表明BPH发生与IL－6及其受体有关。此外，还发现55．0％（11／20）BPH组织中IL－6RmRNA含量高于前列腺癌细胞系PC－3m，提示IL－6所介导的融合毒素可能成为治疗BPH新的有效途径。
Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the gene expression of 80 ku IL-6R in 10 normal prostate, 20 benign prostatic hyperplasia (BPH) and prostate cancer cell line PC-3m . The results showed that the expression of IL-6R mRNA in normal prostate tissue was low, while the expression in 43PH tissue was significantly higher than that in normal group (P <0.01), indicating that the occurrence of BPH was related to IL-6 and its receptor. In addition, IL-6R mRNA levels in 55.0% (11/20) BPH tissues were found to be higher than that of the prostate cancer cell line PC-3m, suggesting that IL-6-mediated fusion toxin may be a new effective approach for the treatment of BPH.