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目的探究结肠高位灌洗治疗儿童难治性抗生素相关性腹泻的临床疗效。方法随机抽选2014年8月—2016年8月泰兴市第二人民医院收治的80例难治性抗生素相关性腹泻患儿为研究对象,按照治疗方案的不同,随机分为观察组与对照组,每组40例。给予对照组停用抗生素、补充电解质以及纠正体内酸碱平衡等临床常规检查治疗,观察组则在此基础上进行结肠高位灌洗治疗。治疗过程中,观察记录两组患儿的大便性状变化情况以及大便次数、腹泻持续时间、大便性状异常持续时间等各项临床指标。结果观察组的各类大便性状改善程度大于对照组;观察组的大便次数、腹泻持续时间、大便性状异常持续时间以及住院时间等各项临床指标均优于对照组的对应值;观察组的治疗总有效率为97.50%,明显高于对照组的80.00%,差异有统计学意义(P<0.05)。结论采取结肠高位灌洗治疗儿童难治性抗生素相关性腹泻,不仅能使患儿的各类大便性状明显好转,还能显著改善患儿各项临床指标。
Objective To investigate the clinical efficacy of high colon lavage in children with refractory antibiotic-associated diarrhea. Methods Totally 80 children with refractory antibiotic-associated diarrhea who were admitted to Second People’s Hospital of Taixing from August 2014 to August 2016 were selected as study subjects and randomly divided into observation group and control group according to different treatment plans , 40 cases in each group. Give the control group to disable antibiotics, electrolyte supplementation and to correct the body acid-base balance and other clinical routine examination and treatment, the observation group is based on this high colon lavage treatment. During the course of treatment, changes of stool traits and stool frequency, duration of diarrhea and abnormal stool stool duration were observed and recorded. Results The observation group had more stools improvement than the control group. The stool frequency, the duration of diarrhea, the duration of abnormal stool and hospital stay in the observation group were all better than those in the control group. The observation group The total effective rate was 97.50%, significantly higher than 80.00% of the control group, the difference was statistically significant (P <0.05). Conclusion High colon lavage treatment of intractable antibiotic-associated diarrhea in children not only can significantly improve the children’s various stool traits, but also significantly improve the clinical indicators in children.