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本文以姐妹染色单体互换(SCE)频率及外周血淋巴细胞染色体断裂率为指标,对25例化疗中及50例化疗后恶性滋养细胞肿瘤患者,调查化疗药物的有害影响。25例化疗中病例连续3个疗程观察结果表明,化疗前后SCE及染色体断裂率于绒癌及恶葡均无明显差异(P>0.05),不同药物间染色体变化亦无明显差异(P>0.05)。于化疗中病例,在第一疗程
In this paper, the sister chromatid exchange (SCE) frequency and peripheral blood lymphocyte chromosome rupture rate as an indicator of chemotherapy in 25 cases of chemotherapy and 50 cases of malignant trophoblastic tumor patients to investigate the harmful effects of chemotherapy drugs. There were no significant differences in SCE and chromosome breakage rate between choriocarcinoma and cesarean section before and after chemotherapy (P> 0.05), and there was no significant difference in chromosomal changes between different drugs (P> 0.05) . In chemotherapy cases, in the first course of treatment