目的：对外用吡哌酸锌软膏经烧伤创面锌吸收进行临床研究。方法：对５６例烧伤总面积２０％以上病人随机分２组——外用吡哌酸锌软膏组和磺胺嘧啶银霜剂组，分别于用药前后不同时间点测血清锌并检测本地正常人血清锌作参照值。结果：２组烧伤病人用药前血清锌均为低值。虽吡哌酸锌软膏组用药后血清锌有所升高，但各时间点其峰值未达正常水平，２４ｈ后又回落到用药前的低值。结论：外用吡哌酸锌软膏锌经烧伤创面有一定吸收，但吸收量甚微。 OBJECTIVE: To study the clinical effect of zinc piperazepinate ointment on absorption of zinc in burn wounds. Methods: Fifty-six patients with over 20% of burn area were randomly divided into two groups: topical zinc piperazepinate group and silver sulfadiazine cream group. Serum zinc was measured at different time points before and after treatment, and the levels of serum zinc As a reference value. Results: Serum zinc was low before treatment in 2 groups of burn patients. Although zinc piperzine ointment group serum zinc levels have increased, but the peak at each time point has not reached the normal level, and then dropped back to a low value before treatment. Conclusion: Topical zinc zipeprazide ointment has a certain absorption on the burn wounds, but the absorption is insignificant.