论文部分内容阅读
目的探讨盐酸多西环素与苄星青霉素治疗梅毒患者的临床疗效。方法选取2012年10月至2014年10月吉化集团公司总医院皮肤性病科收治的梅毒患者资料182例,按随机数字表法将其分为对照组与观察组,各91例。对照组患者肌内注射苄星青霉素,观察组患者口服盐酸多西环素。比较两组患者的临床疗效、不良反应发生以及血清试验转阴情况。结果两组患者的临床总有效率、不良反应发生率差异均无统计学意义(均P>0.05);两组患者中,Ⅰ期与Ⅱ期患者经治疗12个月后梅毒血清试验均呈阴性,总转阴率均明显高于潜伏期组,差异均有统计学意义(均P<0.05)。结论采用盐酸多西环素与苄星青霉素治疗梅毒患者的临床疗效与安全性基本相当,盐酸多西环素可作为临床替代性药物。
Objective To investigate the clinical efficacy of doxycycline hyclate and benzathine penicillin in the treatment of syphilis. Methods A total of 182 patients with syphilis admitted to Department of Dermatology, Jilin University General Hospital from October 2012 to October 2014 were selected and divided into control group and observation group according to random number table method, each with 91 cases. The control group received intramuscular injection of benzathine penicillin and the observation group received oral administration of doxycycline hydrochloride. The clinical efficacy, adverse reactions and negative serum test were compared between the two groups. Results There was no significant difference in clinical total effective rate and incidence of adverse reactions between the two groups (all P> 0.05). In both groups, the syphilis serum test was negative after 12 months of treatment in stage I and stage II patients , The total negative conversion rate were significantly higher than the latency group, the difference was statistically significant (P <0.05). Conclusion The clinical efficacy and safety of doxycycline hyclate and benzathine penicillin in the treatment of syphilis are basically the same, and doxycycline hyclate can be used as a clinical alternative medicine.