１９８７年Ｃｏｕｒｓａｇｅｔ等首次报道发现有ＨＢＶ感染者血清中测不到抗－ＨＢｃ，并将其血清中的这种病毒命名为乙型肝炎病毒２（ＨＢＶ－２）型，随后，各国均有报道。我们对２．７万例ＨＢｓＡｇ阳性的原始检测记录进行回顾性调查，具有上述血清学特征者占４％，并对收集到的２５例血清样品进行了严格鉴定，结果显示其中绝大多数（８０％，２０／２５）仍为ＨＢＶ感染，２０％（５／２５）各项乙型肝炎指标全阴性，其中有７例为抗－ＨＢｃ阴性，但它们的核心基因，经Ｈ８Ｖ－ＤＮＡ－ＰＣＲ扩增仍为阳性。本研究未发现有与ＨＢＶ不同的毒株。 In 1987, Coursaget et al. First reported that anti-HBc was undetectable in the sera of patients with HBV infection and named HBV-2 in their serum. Subsequently, various countries reported it. We retrospectively surveyed 27,000 HBsAg-positive primary test records, accounting for 4% of the above serological features, and rigorously identified 25 serum samples collected, most of which (80 %, 20/25) were still HBV infection. All 20% (5/25) of all hepatitis B were negative, of which 7 were anti-HBc negative, but their core genes were amplified by H8V-DNA-PCR Increased is still positive. The study found no different strains of HBV.