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目的:观察益气固本胶囊对肺气虚小鼠血清中IL-2、IL-10和IL-12含量的影响,探讨该药防治支气管哮喘的作用机制。方法:将96只小鼠(雌雄各半)均分为正常对照、模型、益气固本胶囊高剂量、中剂量、低剂量、玉屏风散颗粒对照6个组,除正常组外其余各组小鼠均采用改良烟熏法复制肺气虚证小鼠模型,分别摘眼球取血,采用ELISA法检测各组小鼠血清中IL-2、IL-10和IL-12的含量并比较。结果:益气固本胶囊高、中剂量组和玉屏风散颗粒组小鼠血清IL-2、IL-10和IL-12含量明显高于模型组。结论:益气固本胶囊可提高肺气虚小鼠血清中IL-2、IL-10和IL-12的水平。
Objective: To observe the effect of Yiqi Guben Capsule on IL-2, IL-10 and IL-12 in the serum of mice with deficiency of lung Qi and to explore the mechanism of action of Yiqi Guben Capsule in preventing and treating bronchial asthma. Methods: Ninety-six mice (male and female) were divided into 6 groups: normal control, model, Yiguxian capsule high dose, middle dose, low dose and Yupingfengsan granule control group, except the normal group The mice were all treated with modified smoked method to copy the lung-Qi deficiency syndrome mice model. The blood samples were taken from the eyeball and the levels of IL-2, IL-10 and IL-12 in the serum were detected by ELISA. Results: The contents of IL-2, IL-10 and IL-12 in serum of Yiqigu Gengben capsule high and medium dose groups and Yupingfengsan Granules group were significantly higher than those of model group. Conclusion: Yiqi Guben Capsule can increase the levels of IL-2, IL-10 and IL-12 in serum of mice with deficiency of lung Qi.