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为了观察在放疗的同期追加化疗能否提高对中晚期食管癌的疗效，将１５６ 例中晚期食管癌随机分成Ａ、Ｂ２ 组，每组７８ 例。Ａ组：每周放疗６ 次，每次２ Ｇｙ；Ｂ组：放疗方式同Ａ 组，另于周末（ 放疗休息日）化疗，ＰＤＤ２０ ｍｇ 、５Ｆｕ ０．５ ｇ／ｍ ２ ，静脉滴注共５ 次。各组照射总肿瘤量为６４ ～７０ Ｇｙ 。随访结果：１、２、３ ａ 生存率，Ａ组分别为６９ ．２ ％（５４／７８） 、２３．１ ％ （１８／７８）和１２ ．８ ％ （１０／７８） ；Ｂ 组分别为７９ ．５％ （６２／７８）、４８ ．７％ （３８／７８）和２０．５ ％（１６／７８）。Ｂ 组２ ａ 生存率明显高于Ａ 组（Ｐ＜ ０．０１），１、３ ａ 生存率２ 组无显著性差异（Ｐ＞ ０．０５）。结果显示，采用每周６ 次、每次２ Ｇｙ 放疗＋ 周末化疗方式治疗中晚期食管癌，近期疗效优于单纯放疗组，无明显毒副作用。
In order to observe whether concurrent chemotherapy with radiotherapy can improve the efficacy of advanced esophageal cancer, 156 patients with advanced esophageal cancer were randomly divided into A and B2 groups, with 78 cases in each group. Group A: weekly radiotherapy 6 times, 2 Gy each time; Group B: radiotherapy in the same way as Group A, and chemotherapy on the weekend (radiotherapy rest day), PDD 20 mg, 5-Fu 0.5 g/m 2 , intravenous drip A total of 5 times. The total tumor volume irradiated in each group was 64 to 70 Gy. Follow-up results: 1, 2, 3 a survival rate, A group was 69. 2% (54/78), 23.1 % (18/78) and 12. 8% (10/78); Group B were 79. 5% (62/78), 48. 7% (38/78) and 20.5 % (16/78). The 2-year survival rate in group B was significantly higher than that in group A (P<0.01), and the 1-year and 3-year survival rates in group 2 were not significantly different (P> 0.05). The results showed that the use of 6 Gy radiotherapy weekly + weekend chemotherapy for the treatment of advanced esophageal cancer, the short-term efficacy is better than the radiotherapy alone group, no significant side effects.