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目的探讨2型糖尿病(T2DM)患者发生糖尿病视网膜病变(DR)的影响因素。方法285例T2DM患者依据检查结果是否患有DR分为DR组(165例)和非DR组(120例),比较两组患者临床资料,并进一步分析T2DM患者发生DR的影响因素。结果两组年龄、性别构成比、BMI、SBP、DBP、左/右眼矫正视力、晶体核硬度分级、FBG、尿素氮、肌酐、尿酸、TG、TC、HDL-C、LDL-C等指标比较差异无统计学意义(P>0.05),而糖尿病病程、视网膜动脉硬化分级、HbA1c比较差异有统计学意义(P<0.01)。多因素Logistic回归分析结果显示,糖尿病病程、视网膜动脉硬化分级、HbA1c为T2DM患者发生DR的独立影响因素(P<0.05)。结论糖尿病病程、视网膜动脉硬化分级、HbA1c与DR的发生、发展具有密切关联,通过监控其动态变化可为DR的防治提供重要的参考依据。
Objective To investigate the influencing factors of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM). Methods A total of 285 T2DM patients were divided into DR group (165 cases) and non-DR group (120 cases) according to the results of the examination. The clinical data of the two groups were compared and the influencing factors of DR in T2DM patients were further analyzed. Results The age, gender composition ratio, BMI, SBP, DBP, left / right eye corrected visual acuity, crystal nucleus hardness grade, FBG, urea nitrogen, creatinine, uric acid, TG, TC, HDL-C and LDL- There was no significant difference between the two groups (P> 0.05). However, the duration of diabetes, grade of retinal atherosclerosis and HbA1c were significantly different (P <0.01). Multivariate Logistic regression analysis showed that diabetes duration, retinal atherosclerosis grade and HbA1c were independent risk factors for DR in T2DM patients (P <0.05). Conclusions Diabetes mellitus, retinal atherosclerosis grading, HbA1c and the occurrence and development of DR are closely related. Monitoring the changes of HbA1c may provide an important reference for the prevention and treatment of DR.