为了观察6-硫鸟嘌呤(6-TG)对性腺组织的影响,给幼年及成年SD大鼠分別服用小剂量和大剂量的6-TG。结果显示,服药成年大鼠睾丸组织结构正常,生精细胞排列整齐,曲细精管中有精子形成,附睾可见形态正常的精子;处于生殖发育期的幼年大鼠亦未发现异常。实验提示,6-TG对大鼠性腺无明显损伤作用,这为6-TG临床应用的安全性提供了理论依据。 In order to observe the effect of 6-thioguanine (6-TG) on gonadal tissues, young and adult SD rats were given low-dose and high-dose 6-TG. The results showed that the structure of testis in normal rats was normal, the spermatogenic cells were arranged neatly, the spermatozoa were formed in the seminiferous tubules and the spermatozoa were found in the epididymis. No abnormalities were found in the young rats during reproductive development. Experimental results suggest that 6-TG has no significant effect on the gonads of rats, which provides a theoretical basis for the safety of 6-TG clinical application.