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探讨一新的毒力因子相关基因群 cag致病岛中cagⅠ部分在中国人群感染幽门螺杆菌 (Hp)中的检出率及其与临床疾病的关系。采用PCR方法检测了 10 7例临床分离培养的Hp菌株 ,扩增cagⅠ中的 170bp片段。结果 :cagⅠ的阳性检出率为 86 .9% ,在慢性胃炎、消化性溃疡、胃癌等疾病间的检出无显著差异 (P >0 .0 5 )。并且与胃粘膜组织的淋巴细胞、浆细胞、嗜中性粒细胞等炎症细胞的浸润程度无关 (P >0 .0 5 )。结论 :cagⅠ在中国人群感染Hp中的检出率很高 ,在慢性胃炎、消化性溃疡、胃癌等疾病中均有相当高的检出率 ,但其检出率在疾病间比较无统计学差异。
To investigate the detection rate of cagⅠ in cag pathogenicity island of a virulence factor related gene cluster in Helicobacter pylori (Hp) and its relationship with clinical disease in Chinese population. A total of 107 strains of Hp strains isolated from clinical isolates were detected by PCR and the 170 bp fragment of cag Ⅰ was amplified. Results: The positive detection rate of cag Ⅰ was 86.9%. There was no significant difference between chronic gastritis, peptic ulcer and gastric cancer (P> 0.05). And gastric mucosal lymphocytes, plasma cells, neutrophils and other infiltration of inflammatory cells has nothing to do (P> 0.05). Conclusion: The detection rate of cag Ⅰ in Chinese population is very high, and it has a very high detection rate in chronic gastritis, peptic ulcer and gastric cancer, but the detection rate is not significantly different between diseases .