由于狂犬病致死率达100%,通过动物咬伤或甚至通过完整粘膜接触动物传染性唾液可使30～40%的人感染狂犬病,因此,关键是要避免疫苗免疫失败。德国Behringwerke AG药物监督局接到报告,在一些狂犬病发病率高的国家,使用疫苗免疫预防狂犬病失败,因此,他们对1985～1990年间泰国和印度报告的15例接触后使用Behring约厂生产的精制鸡胚细胞狂犬病疫苗(效力≥2.5IU/ml)无效的病例进行了分析。分析结果表明,除1例为角膜移植感染外均为狗咬伤。多部位和深部咬伤6例,头 Since rabies lethal rates are 100%, 30-40% of humans become infected with rabies through animal bites or even through intact mucosal contact with animal infectious saliva, so it is critical to avoid vaccine immunization failures. Behringwerke AG, Germany, received reports that vaccine immunization against rabies in some countries with a high incidence of rabies failed to respond to the 15 cases reported by Thailand and India between 1985 and 1990 using Behring plant Chicken embryo cell rabies vaccine (efficacy ≥ 2.5IU / ml) invalid cases were analyzed. Analysis results show that except one case of corneal transplant infection are dog bites. Multi-site and deep bite in 6 cases, head