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许多组织化学研究已显示胃癌细胞可产生胃蛋白酶原(pepsinogen,PEP)同功酶;由于胃粘膜亦衍生PEP同功酶,产生高血和尿浓度,故不易检测由胃癌细胞产生的微量PEP同功酶。然而,当全胃被切除,血和尿PEP同功酶浓度降至低水平时,则可能测检到胃癌细胞产生的小量的PEP同功酶。测定早期(9例)和晚期(6例)胃癌全胃切除术后至少5年无复发的15例尿标本中PEPⅠ的临界水平。对74例胃癌作全胃切除者每3个月
Many histochemical studies have shown that gastric cancer cells can produce pepsinogen (PEP) isoenzyme; since gastric mucosa also derives PEP isoenzyme, resulting in high blood and urine concentrations, it is not easy to detect trace PEP produced by gastric cancer cells. Functional enzyme. However, when the total stomach is removed and the plasma and urinary PEP isoenzyme concentration is reduced to a low level, a small amount of PEP isoenzyme produced by gastric cancer cells may be detected. The critical levels of PEPI in 15 urine specimens without recurrence at least 5 years after total gastrectomy in early stage (9 cases) and late stage (6 cases) were measured. Complete gastrectomy for 74 cases of gastric cancer every 3 months