目的探讨 c- myc蛋白在急性髓系细胞白血病细胞中的表达极其临床意义。方法采用免疫细胞组织化学染色方法 ,检测 2 0例急性髓系细胞白血病病人化疗前后及 2 0例非白血病病人的 c- m yc蛋白的表达水平。结果白血病组 c- m yc蛋白表达较非白血病组明显增高 ,两者呈显著性差异 (P<0 .0 1)。白血病组中 ,化疗后完全缓解与不缓解病人 c- m yc基因的表达有显著性差异 (P<0 .0 5 )。结论 c- myc蛋白在急性髓系细胞白血病细胞中高表达 ,而且与化疗疗效密切相关 ,提示 c- myc蛋白的检测对于急性髓系细胞白血病的诊断、疗效评价及预后估计均有一定意义。 Objective To investigate the clinical significance of the expression of c-myc protein in acute myeloid leukemia cells. Methods Immunocytochemical staining was used to detect the expression of c-myc protein in 20 patients with acute myeloid leukemia before and after chemotherapy and in 20 non-leukemia patients. Results The expression of c-myc protein in leukemia group was significantly higher than that in non-leukemia group (P<0.01). In the leukemia group, there was a significant difference in the expression of c-myc gene between patients with and without remission after chemotherapy (P<0.05). Conclusion The c-myc protein is highly expressed in acute myeloid leukemia cells and is closely related to the efficacy of chemotherapy, suggesting that the detection of c-myc protein is of significance in the diagnosis, therapeutic evaluation and prognosis estimation of acute myeloid leukemia.