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在爱滋病患者中,由婴儿利什曼原虫所致的内脏利什曼病难以治疗,这是因为寄生虫的耐药性和高复发率.存在着对锑制剂和两性霉素B的替代药物,尤其是口服有效药物的需求.甲硝唑和固醇生物合成抑制剂(酮康唑、氟康唑、伊曲康唑和特比萘芬)口服后患者耐受良好,对利什曼原虫具有强活性,但用于治疗不同利什曼原虫引起的皮肤和内脏利什曼病的结果不吻合.一项实验是在治疗开始后第20日时,用培养物微量滴定法测定治疗7～17d的小鼠肝和牌中寄生虫的数量,以评价药物的活性.每日经口腔给药的剂量为:甲硝唑70和140mg/kg,酮康唑50和100mg/kg,氟康唑50和100mg/kg,伊曲康唑50和100mg/kg,特比萘芬100mg/kg.对照药葡甲胺锑酸盐每日剂量
Among AIDS patients, visceral leishmaniasis caused by Leishmania infantum is difficult to treat because of the drug resistance and high recurrence rate of parasites There are alternatives to antimony preparations and amphotericin B, In particular, there is a need for an orally effective drug.Metronidazole and steroid biosynthesis inhibitors (ketoconazole, fluconazole, itraconazole, and terbinafine) are well tolerated after oral administration and have But not for the treatment of leishmaniasis-induced cutaneous and visceral leishmaniasis in an animal model.An experiment was performed on the 20th day after the start of treatment with a culture microtitration assay for 7-17 days Mouse liver and the number of parasites in the card to evaluate the activity of the drug.The daily oral doses were metronidazole 70 and 140 mg / kg, ketoconazole 50 and 100 mg / kg, fluconazole 50 And 100 mg / kg, itraconazole 50 and 100 mg / kg, terbinafine 100 mg / kg Control drug meglumine antimonate daily dose