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目的:探讨p33ING1在结直肠癌中的表达及意义。方法:应用免疫组化S-P法检测60例结直肠癌组织及相应正常黏膜组织中p33ING1的表达。结果:结直肠癌组织、相应正常黏膜组织中p33ING1蛋白的阳性表达率分别为43·3%(26/60)、100%(60/60)。p33ING1在无淋巴结转移组及淋巴结转移组癌组织中的阳性表达率分别为57·6%(19/33)、25·9%(7/27)(P<0·05);在Dukes A、B期、Dukes C、D期病例中分别为56·7%(17/30)、30·0%(9/30)(P<0·05)。结论:p33ING1在结直肠癌组织中低表达,在结直肠癌的发生、发展中可能起重要作用。
Objective: To investigate the expression of p33ING1 in colorectal cancer and its significance. Methods: The expression of p33ING1 in 60 cases of colorectal cancer tissues and corresponding normal mucosa was detected by immunohistochemical S-P method. Results: The positive rates of p33ING1 protein in colorectal cancer tissues and corresponding normal mucosa tissues were 43.3% (26/60) and 100% (60/60), respectively. The positive expression rates of p33ING1 in cancer tissues without lymph node metastasis and lymph node metastasis were 57.6% (19/33) and 25.9% (7/27) respectively (P <0.05). In Dukes A, In stage B, Dukes C and D cases were 56.7% (17/30) and 30.0% (9/30) respectively (P <0.05). Conclusion: The low expression of p33ING1 in colorectal cancer tissues may play an important role in the development of colorectal cancer.