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T 细胞分化在人类胸腺内是未成熟的 T 细胞随着成熟过程,胸腺细胞丢失抗原 T_9,保留T_(10)。获得T_6,同时,这些细胞表达出 T_4、T_(5/8)抗原。随后成熟的 T 细胞都获得充分表达 T_1和 T_3抗原,并分化成为独特的 T_4~+与 T_(5/8)~+两亚群。成熟循环中的 T_1~+、T_3~+、T_4~+细胞和 T_1~+、T_3~+、T_(5/8)~+细胞,分别代表功能相反的细胞亚群,它们分别占 T 细胞数50~60%及30%。这些亚群细胞具有很强的调节作用和效应细胞功
T cell differentiation is immature T cells in the human thymus. With maturation, thymocytes lose antigen T_9 and retain T_ (10). At the same time, these cells expressed T_4 and T_ (5/8) antigens. Subsequent maturation of T cells are fully expressed T_1 and T_3 antigen, and differentiate into a unique T_4 ~ + and T_ (5/8) ~ + two subgroups. T_1 ~ +, T_3 ~ +, T_4 ~ + cells and T_1 ~ +, T_3 ~ +, T_ (5/8) ~ + cells in mature circulation represent the cell subsets with opposite function, 50 to 60% and 30%. These subpopulations have strong regulatory and effector cell functions