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目的 :研究健康志愿者静脉滴注 80mg国产OME注射剂的药动学和药效学。方法 :采用HPLC法测定OME的血药浓度 ,2 4小时动态胃内 pH监测来评价药效。 结果 :血药浓度 时间曲线符合二室开放模型 ,2 4小时胃内 pH平均为 6 2 1± 0 49,pH >4时间占总时间为 (90 5 3± 7 86 ) %。结论 :静脉滴注 80mg国产OME可显著抑制胃酸分泌 ,但抑制胃酸作用与血药浓度不相关。
Objective: To study the pharmacokinetics and pharmacodynamics of intravenous injection of 80mg OME injection in healthy volunteers. Methods: The plasma concentration of OME was measured by HPLC, and the dynamic gastric pH monitoring was performed in 24 hours to evaluate the efficacy. Results: The time curve of plasma concentration conformed to the two-compartment open model. The mean intragastric pH was 2421 ± 0 49 in 24 hours, and the total time of pH> 4 was (90 5 3 ± 7 86)%. Conclusion: Intravenous injection of 80mg OME can significantly inhibit gastric acid secretion, but the inhibition of gastric acid and blood concentration is not related.