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目的探讨硫酸皮肤素(DS)在分娩前后子痫前期患者体内的变化情况。方法选择2010年3～12月在大连市妇产医院产科病房住院并拟行剖宫产的轻度子痫前期患者40例(轻度组)和重度子痫前期患者40例(重度组)及同期住院并拟行剖宫产的正常妊娠晚期妇女40例(对照组)为观察对象,采用发色底物法检测观察对象分娩前后体内DS抗凝活性。结果 (1)产前血浆DS含量:重度组为(0.272±0.075)μg/ml、轻度组为(0.223±0.038)μg/ml、对照组为(0.216±0.032)μg/ml,重度组较轻度组和对照组均明显增高(P<0.05),轻度组与对照组比较差异无统计学意义(P>0.05)。(2)产后血浆DS含量:重度组为(0.105±0.06)μg/ml、轻度组为(0.096±0.067)μg/ml、对照组为(0.083±0.064)μg/ml,3组产妇血浆DS含量较产前均明显降低(P均<0.05),且均恢复接近正常,而重度组较轻度组和对照组仍轻微增高,但无统计学差异(P>0.05)。结论子痫前期患者体内DS水平增高,分娩后降低;DS可作为监测子痫前期患者病情严重程度的指标。
Objective To investigate the changes of dermatan sulfate (DS) in preeclampsia patients before and after labor. Methods 40 cases of mild preeclampsia patients (mild group) and 40 severe preeclampsia patients (severe group) who were hospitalized in maternity wards of Dalian Maternity Hospital from March to December 2010 were enrolled. In the same period, 40 normal women with late pregnancy who were hospitalized for cesarean section were selected as the control group. The chromogenic substrate method was used to detect the in vivo DS anticoagulant activity before and after labor. Results (1) Prenatal plasma DS content was (0.272 ± 0.075) μg / ml in severe group, (0.223 ± 0.038) μg / ml in mild group, and 0.216 ± 0.032 μg / ml in control group Mild group and control group were significantly increased (P <0.05), mild group and the control group showed no significant difference (P> 0.05). (2) Postpartum plasma DS levels were (0.105 ± 0.06) μg / ml in severe group, (0.096 ± 0.067) μg / ml in mild group, and 0.083 ± 0.064 μg / ml in control group (P <0.05), and all recovered to near normal, while the severe group was slightly higher than the mild group and the control group is still slightly increased, but no significant difference (P> 0.05). Conclusions The level of DS in patients with preeclampsia increased and decreased after delivery. DS may be used as an indicator to monitor the severity of preeclampsia.