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目的对血清半胱氨酸蛋白酶抑制蛋白C(CysC)在颅脑损伤继发肾功能损伤中的应用价值进行评估。方法回顾性分析39例颅脑损伤继发肾功能损伤患者和38例体检正常者血清CysC、血清肌酐(SCr)、尿素氮(BUN)、尿酸(UA)实验室检测结果,并进行分析评价。结果患者组血清CysC浓度和CysC异常检出率均明显高于正常组,差异有统计学意义(P<0.01),而SCr、UA和BUN高于健康对照组(P<0.05);同组之间异常检出率比较,患者组血清CysC的异常检出率明显高于血清SCr、UA和BUN,差异有统计学意义(P<0.01);对照组血清CysC等四项检验指标的异常检出率差异无统计学意义(P>0.05)。结论颅脑损伤继发肾功能损伤时血清CysC比传统肾功能检测项目有更高的敏感性和特异性,临床医生应重视血清Cys C在肾功能损害早期诊断的应用价值。
Objective To evaluate the value of serum cystatin C (CysC) in the injury of renal function secondary to craniocerebral injury. Methods The laboratory tests of serum CysC, serum creatinine (SCr), blood urea nitrogen (BUN) and uric acid (UA) in 39 patients with traumatic brain injury secondary to renal dysfunction and 38 healthy controls were retrospectively analyzed. Results The detection rates of serum CysC and CysC abnormalities in patients were significantly higher than those in normal controls (P <0.01), while SCr, UA and BUN were higher than those in healthy controls (P <0.05) The detection rate of abnormal CysC in patients was significantly higher than that of serum SCr, UA and BUN (P <0.01). The abnormality of CysC in the control group was detected The difference was not statistically significant (P> 0.05). Conclusions Serum CysC is more sensitive and specific than the traditional renal function test in traumatic brain injury after renal injury. Clinicians should pay more attention to the value of serum Cys C in early diagnosis of renal damage.