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本文应用荧光分光光度法研究了甲氨喋呤脂质体冻干粉针在几种输液中药物释放动力学。结果表明:甲氨喋呤脂质体的药物释放速率符合一级动力学方程。甲氨喋呤脂质体在不同输液中药物释放速率常数不同。温度升高、药物释放速率常数增大。
In this paper, the release kinetics of methotrexate liposome lyophilized powder injection in several infusion solutions was studied by fluorescence spectrophotometry. The results showed that the drug release rate of methotrexate liposomes conformed to the first-order kinetic equation. Methotrexate liposomes in different infusion drug release rate constant. With increasing temperature, the rate constant of drug release increases.