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目的 :研究健中愈疡片对乙酸诱发胃溃疡大鼠血清肿瘤坏死因子 -α(TNF-α)水平的影响。方法 :制备乙酸诱发大鼠胃溃疡模型 ,分别予健中愈疡片、雷尼替丁和 0 .85 %氯化钠溶液治疗 14 d后 ,测量胃溃疡面积 ;用放射免疫分析法测定大鼠血清 TNF-α水平。结果 :健中愈疡片和雷尼替丁组的胃溃疡面积明显小于 0 .85 %氯化钠溶液组 (P <0 .0 1) ,经过 14 d药物治疗后 ,健中愈疡片组血清 TNF-α水平明显下降 ,与 0 .85 %氯化钠溶液组和雷尼替丁组比较差异有显著性意义 (P <0 .0 5 )。结论 :健中愈疡片能够降低乙酸诱发胃溃疡大鼠的血清 TNF-α水平 ,这可能是其治疗胃溃疡的作用机制之一。
Objective: To investigate the effect of Jianzhong Yuyang Tablet on the level of serum tumor necrosis factor-α (TNF-α) in acetic acid-induced gastric ulcer rats. Methods: The model of gastric ulcer induced by acetic acid in rats was prepared and the area of gastric ulcer was measured after 14 days treatment with Jianzhongyuyang Tablet, ranitidine and 0. 85% sodium chloride solution, respectively. The area of gastric ulcer was measured by radioimmunoassay Serum TNF-α levels. Results: The areas of gastric ulcer in Jianzhongyuyang tablet and ranitidine group were significantly less than those in 085% sodium chloride solution group (P <0.01). After 14 days of drug treatment, Serum TNF-α levels decreased significantly, compared with 0.85% sodium chloride solution group and ranitidine group was significantly different (P <0. 05). Conclusion: Jianzhong Yuyang Tablet can reduce the level of serum TNF-α in acetic acid-induced gastric ulcer rats, which may be one of its mechanisms in the treatment of gastric ulcer.