论文部分内容阅读
在日本,紫苏(Perilla frutescens)作为镇静、解热和抗过敏剂使用。文献报道紫苏叶对培养的鼠性肾小球膜细胞增殖呈较强的抑制作用,还认为抑制肾小球膜细胞增殖是预防肾小球硬化的重要环节。为此进一步研究了紫苏对培养的鼠性肾小球膜细胞增殖的抑制作用,并分离到4种活性成分。 实验材料及方法:紫苏新鲜叶经丙酮水(7:3)室温浸渍4天,浸渍液减压浓缩,得丙酮提取物,提取物先经乙醚/水萃取,
In Japan, Perilla frutescens is used as a sedative, antipyretic and antiallergic agent. It is reported that perilla leaves have a strong inhibitory effect on the proliferation of cultured rat mesangial cells, and it is also believed that the inhibition of mesangial cell proliferation is an important aspect of preventing glomerulosclerosis. For this purpose, the inhibitory effect of perilla on the proliferation of cultured mouse mesangial cells was further studied, and four active ingredients were isolated. Experimental materials and methods: Perilla fresh leaves were impregnated with acetone water (7:3) at room temperature for 4 days. The impregnating solution was concentrated under reduced pressure to obtain acetone extract. The extract was first extracted with ether/water.