Risk analysis of reservoir flood control operation mode with forecast information (FCOMFI) is an important basis for the design and implementation of FCOMFI. Most of current researches on this issue are incomplete as they only consider flood forecast errors, but not many other uncertainties in reservoir routing. In order to obtain an integrated risk rate of FCOMFI, this paper analyzes four uncertainties, i.e. hydrological, hydraulic, stage-storage uncertainty and time-delay uncertainty, as well as their probability distributions. On the basis of this analysis, an integrated risk analysis model of FCOMFI for reservoirs and its lower reach is established involving the above-mentioned four uncertainties, and this model is solved by Monte Carlo simulation based on Latin hypercube sampling. The simulation results, with Baiguishan reservoir as the example, show that the integrated risk rates of FCOMFI are less than those of the flood control operation mode without forecast information. This article presents the highest limited water level that satisfies flood control safety requirements of the lower reach. Risk analysis of reservoir flood control operation mode with forecast information (FCOMFI) is an important basis for the design and implementation of FCOMFI. Most of current researches on this issue are incomplete as they only consider flood forecast errors, but not many other uncertainties in reservoir routing. In order to obtain an integrated risk rate of FCOMFI, this paper analyzes four uncertainties, ie hydrological, hydraulic, stage-storage uncertainty and time-delay uncertainty, as well as their probability distributions. On the basis of this analysis, an integrated risk analysis model of FCOMFI for reservoirs and its lower reach is established involving the above-mentioned four uncertainties, and this model is solved by Monte Carlo simulation based on Latin hypercube sampling. The simulation results, with Baiguishan reservoir as the example, show that the integrated risk rates of FCOMFI are less than those of the flood control operation mode without forecast information article presents the highest limited water level that satisfies flood control safety requirements of the lower reach.